Fluid flow increases mineralized matrix deposition in 3D perfusion culture of marrow stromal osteoblasts in a dose-dependent manner

Bone is a complex highly structured mechanically active 3D tissue composed of cellular and matrix elements. The true biological environment of a bone cell is thus derived from a dynamic interaction between responsively active cells experiencing mechanical forces and a continuously changing 3D matrix...

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Hauptverfasser: Bancroft, Gregory N., Sikavitsas, Vassilios I., van den Dolder, Juliette, Sheffield, Tiffany L., Ambrose, Catherine G., Jansen, John A., Mikos, Antonios G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2002
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC130506/
https://ncbi.nlm.nih.gov/pubmed/12242339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.202296599
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