The Elementary Mass Action Rate Constants of P-gp Transport for a Confluent Monolayer of MDCKII-hMDR1 Cells

The human multi-drug resistance membrane transporter, P-glycoprotein, or P-gp, has been extensively studied due to its importance to human health and disease. Thus far, the kinetic analysis of P-gp transport has been limited to steady-state Michaelis-Menten approaches or to compartmental models, nei...

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Bibliographic Details
Main Authors: Tran, Thuy Thanh, Mittal, Aditya, Aldinger, Tanya, Polli, Joseph W., Ayrton, Andrew, Ellens, Harma, Bentz, Joe
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2005
Subjects:
Cell Biophysics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1305048/
https://ncbi.nlm.nih.gov/pubmed/15501934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.045633
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