Phorbol 12-myristate 13-acetate inhibits P-glycoprotein-mediated efflux of digoxin in MDCKII-MDR1 and Caco-2 cell monolayer models

AIM: To investigate the effects of phorbol 12-myristate 13-acetate (PMA), a PKC activator, on P-glycoprotein-mediated efflux of digoxin in two cell transport models. METHODS: Caco-2 cells, wild MDCKII cells (MDCKII-WT) and MDCKII cells transfected stably with human MDR1-gene encoding P-gp (MDCKII-MD...

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Enregistré dans:
Détails bibliographiques
Publié dans:Acta Pharmacol Sin
Auteurs principaux: Li, Yu-hua, Bi, Hui-chang, Huang, Ling, Jin, Jing, Zhong, Guo-ping, Zhou, Xu-nian, Huang, Min
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2014
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Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4651225/
https://ncbi.nlm.nih.gov/pubmed/24362330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2013.157
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