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Aggregation of Normal and Sickle Hemoglobin in High Concentration Phosphate Buffer

Sickle cell disease is caused by a mutant form of hemoglobin, hemoglobin S, that polymerizes under hypoxic conditions. The extent and mechanism of polymerization are thus the subject of many studies of the pathophysiology of the disease and potential treatment strategies. To facilitate such studies,...

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Detalhes bibliográficos
Main Authors: Chen, Kejing, Ballas, Samir K., Hantgan, Roy R., Kim-Shapiro, Daniel B.
Formato: Artigo
Idioma:Inglês
Publicado em: Biophysical Society 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1304920/
https://ncbi.nlm.nih.gov/pubmed/15465861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.046482
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