Uniform Sampling of Steady-State Flux Spaces: Means to Design Experiments and to Interpret Enzymopathies

Reconstruction of genome-scale metabolic networks is now possible using multiple different data types. Constraint-based modeling is an approach to interrogate capabilities of reconstructed networks by constraining possible cellular behavior through the imposition of physicochemical laws. As a result...

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Bibliographic Details
Main Authors: Price, Nathan D., Schellenberger, Jan, Palsson, Bernhard O.
Format: Artigo
Language:Inglês
Published: Biophysical Society 2004
Subjects:
Biophysical Theory and Modeling
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1304643/
https://ncbi.nlm.nih.gov/pubmed/15454420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.043000
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