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Modeling Noncompetitive Antagonism of a Nicotinic Acetylcholine Receptor

Models of closed and open channel pores of a muscle-type nicotinic acetylcholine receptor (nAChR) channel comprising M1 and M2 segments are presented. A model of the closed channel is proposed in which hydrophobic residues of the Equatorial Leucine ring screen the oxygen domain formed by the Serine...

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Détails bibliographiques
Auteurs principaux: Tikhonov, Denis B., Mellor, Ian R., Usherwood, Peter N. R.
Format: Artigo
Langue:Inglês
Publié: Biophysical Society 2004
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1304339/
https://ncbi.nlm.nih.gov/pubmed/15240454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.103.037457
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