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Computer Simulation of Small Molecule Permeation across a Lipid Bilayer: Dependence on Bilayer Properties and Solute Volume, Size, and Cross-Sectional Area

Cell membrane permeation is required for most drugs to reach their biological target, and understanding this process is therefore crucial for rational drug design. Recent molecular dynamics simulations have studied the permeation of eight small molecules through a phospholipid bilayer. Unlike experi...

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Detaylı Bibliyografya
Asıl Yazarlar: Bemporad, D., Luttmann, C., Essex, J. W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Biophysical Society 2004
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1304332/
https://ncbi.nlm.nih.gov/pubmed/15240439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.103.030601
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