Specific versus Nonspecific Binding of Cationic PNAs to Duplex DNA

Although peptide nucleic acids (PNAs) are neutral by themselves, they are usually appended with positively charged lysine residues to increase their solubility and binding affinity for nucleic acid targets. Thus obtained cationic PNAs very effectively interact with the designated duplex DNA targets...

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Bibliografiske detaljer
Main Authors: Abibi, Ayome, Protozanova, Ekaterina, Demidov, Vadim V., Frank-Kamenetskii, Maxim D.
Format: Artigo
Sprog:Inglês
Udgivet: Biophysical Society 2004
Fag:
Nucleic Acids
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1304173/
https://ncbi.nlm.nih.gov/pubmed/15111421
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