Sequential Immunization with Vesicles Prepared from Heterologous Neisseria meningitidis Strains Elicits Broadly Protective Serum Antibodies to Group B Strains

The capsular polysaccharide of Neisseria meningitidis group B is an autoantigen, whereas noncapsular antigens are highly variable. These factors present formidable challenges for development of a broadly protective and safe group B vaccine. Mice and guinea pigs were sequentially immunized with three...

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Detalhes bibliográficos
Main Authors: Moe, Gregory R., Zuno-Mitchell, Patricia, Hammond, Samantha N., Granoff, Dan M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC130404/
https://ncbi.nlm.nih.gov/pubmed/12379678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.11.6021-6031.2002
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