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Water Accessibility, Aggregation, and Motional Features of Polysaccharide-Protein Conjugate Vaccines

A relaxometric investigation of a nontoxic mutant of diphtheria toxin and of its conjugates with capsular polysaccharides of different groups of Neisseria meningitidis was performed. The insertion of polysaccharides chains alters dramatically the hydrodynamic properties of the protein. The model-fre...

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Autors principals: Berti, Francesco, Costantino, Paolo, Fragai, Marco, Luchinat, Claudio
Format: Artigo
Idioma:Inglês
Publicat: Biophysical Society 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1303793/
https://ncbi.nlm.nih.gov/pubmed/14695244
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