Dynamic NMR Structures of [Rp]- and [Sp]-Phosphorothioated DNA-RNA Hybrids: Is Flexibility Required for RNase H Recognition?

Chemically modified DNA oligonucleotides have been crucial to the development of antisense therapeutics. High-resolution structural studies of pharmaceutically relevant derivatives have been limited to only a few molecules. We have used NMR to elucidate the structure in solution of two DNA-RNA hybri...

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Detaylı Bibliyografya
Asıl Yazarlar: Tonelli, Marco, Ulyanov, Nikolai B., Billeci, Todd M., Karwowski, Boleslaw, Guga, Piotr, Stec, Wojciech J., James, Thomas L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Biophysical Society 2003
Konular:
Nucleic Acids
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1303476/
https://ncbi.nlm.nih.gov/pubmed/14507715
Etiketler: Etiketle
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