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Solid-State NMR Investigation of the Depth of Insertion of Protegrin-1 in Lipid Bilayers Using Paramagnetic Mn(2+)

The depth of insertion of an antimicrobial peptide, protegrin-1 (PG-1), in lipid bilayers is investigated using solid-state NMR. Paramagnetic Mn(2+) ions bind to the surface of lipid bilayers and induce distance-dependent dipolar relaxation of nuclear spins. By comparing the signal dephasing of the...

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Main Authors: Buffy, Jarrod J., Hong, Teresa, Yamaguchi, Satoru, Waring, Alan J., Lehrer, Robert I., Hong, Mei
Formato: Artigo
Idioma:Inglês
Publicado em: Biophysical Society 2003
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1303461/
https://ncbi.nlm.nih.gov/pubmed/14507700
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