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Gating of MscL Studied by Steered Molecular Dynamics

Steered molecular dynamics simulations of the mechanosensitive channel of large conductance, MscL, were used to investigate how forces arising from membrane tension induce gating of the channel. A homology model of the closed form of MscL from Escherichia coli was subjected to external forces of 35–...

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Bibliographic Details
Main Authors: Gullingsrud, Justin, Schulten, Klaus
Format: Artigo
Language:Inglês
Published: Biophysical Society 2003
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1303438/
https://ncbi.nlm.nih.gov/pubmed/14507677
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