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Gating of MscL Studied by Steered Molecular Dynamics

Steered molecular dynamics simulations of the mechanosensitive channel of large conductance, MscL, were used to investigate how forces arising from membrane tension induce gating of the channel. A homology model of the closed form of MscL from Escherichia coli was subjected to external forces of 35–...

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Autori principali: Gullingsrud, Justin, Schulten, Klaus
Natura: Artigo
Lingua:Inglês
Pubblicazione: Biophysical Society 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1303438/
https://ncbi.nlm.nih.gov/pubmed/14507677
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