Three-Dimensional Imaging of Lipid Gene-Carriers: Membrane Charge Density Controls Universal Transfection Behavior in Lamellar Cationic Liposome-DNA Complexes

Cationic liposomes (CLs) are used worldwide as gene vectors (carriers) in nonviral clinical applications of gene delivery, albeit with unacceptably low transfection efficiencies (TE). We present three-dimensional laser scanning confocal microscopy studies revealing distinct interactions between CL-D...

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Main Authors: Lin, Alison J., Slack, Nelle L., Ahmad, Ayesha, George, Cyril X., Samuel, Charles E., Safinya, Cyrus R.
Format: Artigo
Jezik:Inglês
Izdano: Biophysical Society 2003
Teme:
Supramolecular Assemblies
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1302891/
https://ncbi.nlm.nih.gov/pubmed/12719260
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