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Capsaicin Activation of the Pain Receptor, VR1: Multiple Open States from Both Partial and Full Binding

Capsaicin, the pungent ingredient of hot peppers, has long been used to identify nociceptors. Its molecular target, the vanilloid receptor VR1, was recently cloned and confirmed functionally as a polymodal detector of multiple pain stimuli: heat, acid, and vanilloids. Previous electrophysiology stud...

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Autori principali: Hui, Kwokyin, Liu, Beiying, Qin, Feng
Natura: Artigo
Lingua:Inglês
Pubblicazione: Biophysical Society 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1302858/
https://ncbi.nlm.nih.gov/pubmed/12719227
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