Filter Flexibility in a Mammalian K Channel: Models and Simulations of Kir6.2 Mutants

The single-channel conductance varies significantly between different members of the inward rectifier (Kir) family of potassium channels. Mutations at three sites in Kir6.2 have been shown to produce channels with reduced single-channel conductance, the largest reduction (to 40% of wild-type) being...

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Bibliografiske detaljer
Main Authors: Capener, Charlotte E., Proks, Peter, Ashcroft, Frances M., Sansom, Mark S. P.
Format: Artigo
Sprog:Inglês
Udgivet: Biophysical Society 2003
Fag:
Channels, Receptors, and Transporters
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1302801/
https://ncbi.nlm.nih.gov/pubmed/12668443
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