Termination of cardiac Ca(2+) sparks: an investigative mathematical model of calcium-induced calcium release.

A Ca(2+) spark arises when a cluster of sarcoplasmic reticulum (SR) channels (ryanodine receptors or RyRs) opens to release calcium in a locally regenerative manner. Normally triggered by Ca(2+) influx across the sarcolemmal or transverse tubule membrane neighboring the cluster, the Ca(2+) spark has...

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Bibliographic Details
Main Authors: Sobie, Eric A, Dilly, Keith W, dos Santos Cruz, Jader, Lederer, W Jonathan, Jafri, M Saleet
Format: Artigo
Language:Inglês
Published: 2002
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1302127/
https://ncbi.nlm.nih.gov/pubmed/12080100
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