Aggregation and retention of human urokinase type plasminogen activator in the yeast endoplasmic reticulum

BACKGROUND: Secretion of recombinant proteins in yeast can be affected by their improper folding in the endoplasmic reticulum and subsequent elimination of the misfolded molecules via the endoplasmic reticulum associated protein degradation pathway. Recombinant proteins can also be degraded by the v...

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Veröffentlicht in:	BMC Mol Biol
Hauptverfasser:	Agaphonov, Michael O, Romanova, Nina V, Trushkina, Polina M, Smirnov, Vladimir N, Ter-Avanesyan, Michael D
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2002
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC130179/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12366865/ https://ncbi.nlm.nih.govhttps://doi.org/10.1186/1471-2199-3-15
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