Aggregation and retention of human urokinase type plasminogen activator in the yeast endoplasmic reticulum

BACKGROUND: Secretion of recombinant proteins in yeast can be affected by their improper folding in the endoplasmic reticulum and subsequent elimination of the misfolded molecules via the endoplasmic reticulum associated protein degradation pathway. Recombinant proteins can also be degraded by the v...

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Bibliografiske detaljer
Main Authors: Agaphonov, Michael O, Romanova, Nina V, Trushkina, Polina M, Smirnov, Vladimir N, Ter-Avanesyan, Michael D
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2002
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC130179/
https://ncbi.nlm.nih.gov/pubmed/12366865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-3-15
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