Disease-causing mutations in cardiac troponin T: identification of a critical tropomyosin-binding region.

Fifteen percent of the mutations causing familial hypertrophic cardiomyopathy are in the troponin T gene. Most mutations are clustered between residues 79 and 179, a region known to bind to tropomyosin at the C-terminus near the complex between the N- and C-termini. Nine mutations were introduced in...

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Bibliographic Details
Main Authors: Palm, T, Graboski, S, Hitchcock-DeGregori, S E, Greenfield, N J
Format: Artigo
Language:Inglês
Published: 2001
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1301748/
https://ncbi.nlm.nih.gov/pubmed/11606294
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