Microscopic kinetics and energetics distinguish GABA(A) receptor agonists from antagonists.

Although agonists and competitive antagonists presumably occupy overlapping binding sites on ligand-gated channels, these interactions cannot be identical because agonists cause channel opening whereas antagonists do not. One explanation is that only agonist binding performs enough work on the recep...

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Detalles Bibliográficos
Main Authors: Jones, M V, Jonas, P, Sahara, Y, Westbrook, G L
Formato: Artigo
Idioma:Inglês
Publicado: 2001
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1301733/
https://ncbi.nlm.nih.gov/pubmed/11606279
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