Microscopic kinetics and energetics distinguish GABA(A) receptor agonists from antagonists.

Although agonists and competitive antagonists presumably occupy overlapping binding sites on ligand-gated channels, these interactions cannot be identical because agonists cause channel opening whereas antagonists do not. One explanation is that only agonist binding performs enough work on the recep...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Jones, M V, Jonas, P, Sahara, Y, Westbrook, G L
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2001
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1301733/
https://ncbi.nlm.nih.gov/pubmed/11606279
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