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Structure and hydration of the DNA-human topoisomerase I covalent complex.

The structure and hydration of reconstituted human topoisomerase I comprising the core and the carboxyl-terminal domains in covalent complex with 22-basepair DNA duplex has been investigated by molecular dynamics simulation. The structure and the intermolecular interactions were found to be well mai...

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Detalhes bibliográficos
Main Authors: Chillemi, G, Castrignanò, T, Desideri, A
Formato: Artigo
Idioma:Inglês
Publicado em: 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1301528/
https://ncbi.nlm.nih.gov/pubmed/11423431
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