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A direct optimization approach to hidden Markov modeling for single channel kinetics.

Hidden Markov modeling (HMM) provides an effective approach for modeling single channel kinetics. Standard HMM is based on Baum's reestimation. As applied to single channel currents, the algorithm has the inability to optimize the rate constants directly. We present here an alternative approach...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Qin, F, Auerbach, A, Sachs, F
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2000
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1301083/
https://ncbi.nlm.nih.gov/pubmed/11023897
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