M2 pore mutations convert the glycine receptor channel from being anion- to cation-selective.

Three mutations in the M2 transmembrane domains of the chloride-conducting alpha1 homomeric glycine receptor (P250Delta, A251E, and T265V), which normally mediate fast inhibitory neurotransmission, produced a cation-selective channel with P(Cl)/P(Na), = 0.27 (wild-type P(Cl)/P(Na) = 25), a permeabil...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Keramidas, A, Moorhouse, A J, French, C R, Schofield, P R, Barry, P H
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2000
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1300929/
https://ncbi.nlm.nih.gov/pubmed/10866951
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge