Noncontact dipole effects on channel permeation. III. Anomalous proton conductance effects in gramicidin

Proton transport on water wires, of interest for many problems in membrane biology, is analyzed in side-chain analogs of gramicidin A channels. In symmetrical 0.1 N HCl solutions, fluorination of channel Trp(11), Trp-(13), or Trp(15) side chains is found to inhibit proton transport, and replacement...

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Bibliographic Details
Main Authors: Phillips, LR, Cole, CD, Hendershot, RJ, Cotten, M, Cross, TA, Busath, DD
Format: Artigo
Language:Inglês
Published: 1999
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1300525/
https://ncbi.nlm.nih.gov/pubmed/20540928
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