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Constitutive degradation of IκBα in human T lymphocytes is mediated by calpain

BACKGROUND: Activation-induced induction of transcription factor NFκB in T lymphocytes is regulated by its inhibitor IκBα. NFκB activation has been demonstrated to occur either by phosphorylation on serine residues 32 and 36 of the inhibitor, IκBα, followed by ubiquitination and degradation of the i...

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Bibliografiske detaljer
Main Authors: Ponnappan, Subramaniam, Cullen, Sarah J, Ponnappan, Usha
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1298323/
https://ncbi.nlm.nih.gov/pubmed/16271147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4933-2-15
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