The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage

BACKGROUND: Members of the p47 (immunity-related GTPases (IRG) family) GTPases are essential, interferon-inducible resistance factors in mice that are active against a broad spectrum of important intracellular pathogens. Surprisingly, there are no reports of p47 function in humans. RESULTS: Here we...

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Main Authors: Bekpen, Cemalettin, Hunn, Julia P, Rohde, Christoph, Parvanova, Iana, Guethlein, Libby, Dunn, Diane M, Glowalla, Eva, Leptin, Maria, Howard, Jonathan C
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2005
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1297648/
https://ncbi.nlm.nih.gov/pubmed/16277747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2005-6-11-r92
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