Reduced transforming growth factor-beta signaling in cartilage of old mice: role in impaired repair capacity

Osteoarthritis (OA) is a common joint disease, mainly effecting the elderly population. The cause of OA seems to be an imbalance in catabolic and anabolic factors that develops with age. IL-1 is a catabolic factor known to induce cartilage damage, and transforming growth factor (TGF)-beta is an anab...

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Autori principali: Blaney Davidson, EN, Scharstuhl, A, Vitters, EL, van der Kraan, PM, van den Berg, WB
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2005
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1297583/
https://ncbi.nlm.nih.gov/pubmed/16277687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar1833
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