Induction of cyclooxygenase-2 in a mouse model of Peutz–Jeghers polyposis
Inactivating germ-line mutations of LKB1 lead to Peutz–Jeghers syndrome (PJS). We have generated mice heterozygous for a targeted inactivating allele of Lkb1 and found that they develop severe gastrointestinal polyposis. In all cases, the polyps arising in the Lkb1(+/−) mice were found to be hamarto...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC129444/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12218179/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.192301399 |
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