Induction of cyclooxygenase-2 in a mouse model of Peutz–Jeghers polyposis

Inactivating germ-line mutations of LKB1 lead to Peutz–Jeghers syndrome (PJS). We have generated mice heterozygous for a targeted inactivating allele of Lkb1 and found that they develop severe gastrointestinal polyposis. In all cases, the polyps arising in the Lkb1(+/−) mice were found to be hamarto...

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Bibliografiske detaljer
Main Authors: Rossi, Derrick J., Ylikorkala, Antti, Korsisaari, Nina, Salovaara, Reijo, Luukko, Keijo, Launonen, Virpi, Henkemeyer, Mark, Ristimäki, Ari, Aaltonen, Lauri A., Mäkelä, Tomi P.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC129444/
https://ncbi.nlm.nih.gov/pubmed/12218179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.192301399
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