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A functional polymorphism in the promoter of the progesterone receptor gene associated with endometrial cancer risk

Excessive estrogen stimulation unopposed by progesterone strongly predisposes to endometrial cancer. Because the antiproliferative effect of progesterone requires the progesterone receptor (PR), which exists in two isoforms, PR-A and -B, we reasoned that variants in the PR gene may predispose to end...

詳細記述

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書誌詳細
主要な著者: De Vivo, Immaculata, Huggins, Gordon S., Hankinson, Susan E., Lescault, Pamela J., Boezen, Marike, Colditz, Graham A., Hunter, David J.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2002
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC129433/
https://ncbi.nlm.nih.gov/pubmed/12218173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.192172299
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