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A functional polymorphism in the promoter of the progesterone receptor gene associated with endometrial cancer risk
Excessive estrogen stimulation unopposed by progesterone strongly predisposes to endometrial cancer. Because the antiproliferative effect of progesterone requires the progesterone receptor (PR), which exists in two isoforms, PR-A and -B, we reasoned that variants in the PR gene may predispose to end...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2002
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC129433/ https://ncbi.nlm.nih.gov/pubmed/12218173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.192172299 |
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