A functional polymorphism in the promoter of the progesterone receptor gene associated with endometrial cancer risk

Excessive estrogen stimulation unopposed by progesterone strongly predisposes to endometrial cancer. Because the antiproliferative effect of progesterone requires the progesterone receptor (PR), which exists in two isoforms, PR-A and -B, we reasoned that variants in the PR gene may predispose to end...

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Detalhes bibliográficos
Main Authors: De Vivo, Immaculata, Huggins, Gordon S., Hankinson, Susan E., Lescault, Pamela J., Boezen, Marike, Colditz, Graham A., Hunter, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC129433/
https://ncbi.nlm.nih.gov/pubmed/12218173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.192172299
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