A functional polymorphism in the promoter of the progesterone receptor gene associated with endometrial cancer risk

Excessive estrogen stimulation unopposed by progesterone strongly predisposes to endometrial cancer. Because the antiproliferative effect of progesterone requires the progesterone receptor (PR), which exists in two isoforms, PR-A and -B, we reasoned that variants in the PR gene may predispose to end...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: De Vivo, Immaculata, Huggins, Gordon S., Hankinson, Susan E., Lescault, Pamela J., Boezen, Marike, Colditz, Graham A., Hunter, David J.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2002
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC129433/
https://ncbi.nlm.nih.gov/pubmed/12218173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.192172299
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