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Crystal structure of calcineurin–cyclophilin–cyclosporin shows common but distinct recognition of immunophilin–drug complexes

Calcineurin, a Ca(2+)/calmodulin-dependent protein phosphatase, is the common target for two immunophilin–immunosuppressant complexes, cyclophilin A–cyclosporin A (CyPA-CsA) and FKBP–FK506. How the two structurally distinct immunophilin–drug complexes bind the same target has remained unknown. We re...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Huai, Qing, Kim, Hwa-Young, Liu, Yudong, Zhao, Yingdong, Mondragon, Angelo, Liu, Jun O., Ke, Hengming
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC129394/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12218175/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.192206699
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