Crosslinked HIV-1 envelope–CD4 receptor complexes elicit broadly cross-reactive neutralizing antibodies in rhesus macaques

The identification of HIV envelope structures that generate broadly cross-reactive neutralizing antibodies is a major goal for HIV-vaccine development. In this study, we evaluated one such structure, expressed as either a gp120–CD4 or a gp140–CD4 complex, for its ability to elicit a neutralizing ant...

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Bibliografiska uppgifter
Huvudupphovsmän: Fouts, Timothy, Godfrey, Karla, Bobb, Kathryn, Montefiori, David, Hanson, Carl V., Kalyanaraman, V. S., DeVico, Anthony, Pal, Ranajit
Materialtyp: Artigo
Språk:Inglês
Publicerad: The National Academy of Sciences 2002
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC129356/
https://ncbi.nlm.nih.gov/pubmed/12192089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.182412199
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