Short-term antigen presentation and single clonal burst limit the magnitude of the CD8+ T cell responses to malaria liver stages

Malaria sporozoites induce swift activation of antigen-specific CD8+ T cells that inhibit the intracellular development of liver-stage parasites. The length of time of functional in vivo antigen presentation, estimated by monitoring the activation of antigen-specific CD8+ T cells, is of short durati...

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Bibliographische Detailangaben
Hauptverfasser: Hafalla, Julius C. R., Sano, Gen-ichiro, Carvalho, Luzia H., Morrot, Alexandre, Zavala, Fidel
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2002
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC129352/
https://ncbi.nlm.nih.gov/pubmed/12185251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.182189999
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