Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4

Certain IFN regulatory factor (IRF) transcription factors indirectly influence T helper (Th) cell differentiation by regulating the production of IL-12. Here, we show that IRF4 directly regulates Th cell differentiation in vitro and in vivo during murine leishmaniasis. In the absence of IRF4, IL-12-...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Lohoff, Michael, Mittrücker, Hans-Willi, Prechtl, Stefan, Bischof, Susi, Sommer, Frank, Kock, Sonja, Ferrick, David A., Duncan, Gordon S., Gessner, Andre, Mak, Tak W.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2002
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC129350/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12189207/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.182425099
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