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The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin

Suberoylanilide hydroxamic acid (SAHA) is a potent inhibitor of histone deacetylases (HDACs) that causes growth arrest, differentiation, and/or apoptosis of many tumor types in vitro and in vivo. SAHA is in clinical trials for the treatment of cancer. HDAC inhibitors induce the expression of less th...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Butler, Lisa M., Zhou, Xianbo, Xu, Wei-Sheng, Scher, Howard I., Rifkind, Richard A., Marks, Paul A., Richon, Victoria M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC129332/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12189205/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.182372299
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