Hypoxia-Inducible Factors 1α and 2α Regulate Trophoblast Differentiation

Placental development initially occurs in a low-oxygen (O(2)) or hypoxic environment. In this report we show that two hypoxia-inducible factors (HIFs), HIF1α and HIF2α, are essential for determining murine placental cell fates. HIF is a heterodimer composed of HIFα and HIFβ (ARNT) subunits. Placenta...

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Detalhes bibliográficos
Main Authors: Cowden Dahl, Karen D., Fryer, Benjamin H., Mack, Fiona A., Compernolle, Veerle, Maltepe, Emin, Adelman, David M., Carmeliet, Peter, Simon, M. Celeste
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1291235/
https://ncbi.nlm.nih.gov/pubmed/16287860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.23.10479-10491.2005
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