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Anaphase-Promoting Complex/Cyclosome Controls the Stability of TPX2 during Mitotic Exit

TPX2, a microtubule-associated protein, is required downstream of Ran-GTP to induce spindle assembly. TPX2 activity appears to be tightly regulated during the cell cycle, and we report here one molecular mechanism for this regulation. We found that TPX2 protein levels are cell cycle regulated, peaki...

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Autori principali: Stewart, Scott, Fang, Guowei
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1291225/
https://ncbi.nlm.nih.gov/pubmed/16287863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.23.10516-10527.2005
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