Stable Ribosome Binding to the Endoplasmic Reticulum Enables Compartment-specific Regulation of mRNA Translation

In eukaryotic cells, protein synthesis is compartmentalized; mRNAs encoding secretory/membrane proteins are translated on endoplasmic reticulum (ER)-bound ribosomes, whereas mRNAs encoding cytosolic proteins are translated on free ribosomes. mRNA partitioning between the two compartments occurs via...

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Bibliographic Details
Main Authors: Stephens, Samuel B., Dodd, Rebecca D., Brewer, Joseph W., Lager, Patrick J., Keene, Jack D., Nicchitta, Christopher V.
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2005
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1289424/
https://ncbi.nlm.nih.gov/pubmed/16221886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E05-07-0685
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