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Changes in Regulatory Phosphorylation of Cdc25C Ser287 and Wee1 Ser549 during Normal Cell Cycle Progression and Checkpoint Arrests

Entry into mitosis is catalyzed by cdc2 kinase. Previous work identified the cdc2-activating phosphatase cdc25C and the cdc2-inhibitory kinase wee1 as targets of the incomplete replication-induced kinase Chk1. Further work led to the model that checkpoint kinases block mitotic entry by inhibiting cd...

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Detalles Bibliográficos
Main Authors: Stanford, Jennifer S., Ruderman, Joan V.
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Cell Biology 2005
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1289418/
https://ncbi.nlm.nih.gov/pubmed/16195348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E05-06-0541
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