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Meiotic Segregation Analysis of RB1 Alleles in Retinoblastoma Pedigrees by Use of Single-Sperm Typing

In hereditary retinoblastoma, different epidemiological studies have indicated a preferential paternal transmission of mutant retinoblastoma alleles to offspring, suggesting the occurrence of a meiotic drive. To investigate this mechanism, we analyzed sperm samples from six individuals from five unr...

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Bibliografiske detaljer
Main Authors: Girardet, Anne, McPeek, Mary Sara, Leeflang, Esther P., Munier, Francis, Arnheim, Norman, Claustres, Mireille, Pellestor, Franck
Format: Artigo
Sprog:Inglês
Udgivet: The American Society of Human Genetics 2000
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1288323/
https://ncbi.nlm.nih.gov/pubmed/10631148
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