Joint Multipoint Linkage Analysis of Multivariate Qualitative and Quantitative Traits. I. Likelihood Formulation and Simulation Results

We describe a variance-components method for multipoint linkage analysis that allows joint consideration of a discrete trait and a correlated continuous biological marker (e.g., a disease precursor or associated risk factor) in pedigrees of arbitrary size and complexity. The continuous trait is assu...

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Bibliographic Details
Main Authors: Williams, Jeff T., Van Eerdewegh, Paul, Almasy, Laura, Blangero, John
Format: Artigo
Language:Inglês
Published: The American Society of Human Genetics 1999
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1288247/
https://ncbi.nlm.nih.gov/pubmed/10486333
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