Effects of the Des-F(6)-Quinolone Garenoxacin (BMS-284756), in Comparison to Those of Ciprofloxacin and Ofloxacin, on Joint Cartilage in Immature Rats

We did not observe signs of chondrotoxicity in immature rats treated orally with garenoxacin (BMS-284756) at doses up to five times 600 mg/kg of body weight or with ciprofloxacin, whereas ofloxacin induced typical cartilage lesions. The peak plasma garenoxacin concentration was 25.5 mg/liter after a...

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Bibliographic Details
Main Authors: Maria Kappel, Eva, Shakibaei, Mehdi, Bello, Akintunde, Stahlmann, Ralf
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC128797/
https://ncbi.nlm.nih.gov/pubmed/12234871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.10.3320-3322.2002
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