Effects of the Des-F(6)-Quinolone Garenoxacin (BMS-284756), in Comparison to Those of Ciprofloxacin and Ofloxacin, on Joint Cartilage in Immature Rats

We did not observe signs of chondrotoxicity in immature rats treated orally with garenoxacin (BMS-284756) at doses up to five times 600 mg/kg of body weight or with ciprofloxacin, whereas ofloxacin induced typical cartilage lesions. The peak plasma garenoxacin concentration was 25.5 mg/liter after a...

Ausführliche Beschreibung

Bibliografische Detailangaben

Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Maria Kappel, Eva, Shakibaei, Mehdi, Bello, Akintunde, Stahlmann, Ralf
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2002
Schlagworte:	Pharmacology
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC128797/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12234871/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.10.3320-3322.2002
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!