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Inhibition of Human Immunodeficiency Virus Type 1 Isolates by the Integrase Inhibitor L-731,988, a Diketo Acid

L-731,988 inhibits human immunodeficiency virus (HIV) replication through integrase. In this study, approximately 600 nM L-731,988 inhibited the replication of 12 HIV type 1 isolates from multiple clades, including primary isolates and cloned viruses. These data suggest that diketo acids or their de...

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Published in:Antimicrob Agents Chemother
Main Authors: Reinke, Ryan, Lee, Deborah J., Robinson, Jr., W. Edward
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2002
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC128787/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12234866/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.10.3301-3303.2002
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