Itraconazole Preexposure Attenuates the Efficacy of Subsequent Amphotericin B Therapy in a Murine Model of Acute Invasive Pulmonary Aspergillosis

Antagonism has been described in vitro and in vivo for azole-polyene combinations against Aspergillus species. Using an established murine model of invasive pulmonary aspergillosis, we evaluated the efficacy of several amphotericin B (AMB) dosages given alone or following preexposure to itraconazole...

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Autors principals: Lewis, Russell E., Prince, Randall A., Chi, Jingduan, Kontoyiannis, Dimitrios P.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2002
Matèries:
Experimental Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC128771/
https://ncbi.nlm.nih.gov/pubmed/12234846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.10.3208-3214.2002
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