Itraconazole Preexposure Attenuates the Efficacy of Subsequent Amphotericin B Therapy in a Murine Model of Acute Invasive Pulmonary Aspergillosis

Antagonism has been described in vitro and in vivo for azole-polyene combinations against Aspergillus species. Using an established murine model of invasive pulmonary aspergillosis, we evaluated the efficacy of several amphotericin B (AMB) dosages given alone or following preexposure to itraconazole...

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Détails bibliographiques

Publié dans:	Antimicrob Agents Chemother
Auteurs principaux:	Lewis, Russell E., Prince, Randall A., Chi, Jingduan, Kontoyiannis, Dimitrios P.
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 2002
Sujets:	Experimental Therapeutics
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC128771/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12234846/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.10.3208-3214.2002
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