Biocatalytic Conversion of Avermectin to 4"-Oxo-Avermectin: Heterologous Expression of the ema1 Cytochrome P450 Monooxygenase

The cytochrome P450 monooxygenase Ema1 from Streptomyces tubercidicus R-922 and its homologs from closely related Streptomyces strains are able to catalyze the regioselective oxidation of avermectin into 4"-oxo-avermectin, a key intermediate in the manufacture of the agriculturally important in...

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Main Authors: Molnár, István, Hill, D. Steven, Zirkle, Ross, Hammer, Philip E., Gross, Frank, Buckel, Thomas G., Jungmann, Volker, Pachlatko, Johannes Paul, Ligon, James M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2005
Assuntos:
Enzymology and Protein Engineering
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1287623/
https://ncbi.nlm.nih.gov/pubmed/16269733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.71.11.6977-6985.2005
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